Meeting the food demand of an increasing population is a major global concern. Reducing post-harvest losses presents a sustainable solution to increased food availability. Cereal grains are the main staple food in most of the developing world and account for the highest post-harvest losses on a calorific basis among all agricultural commodities. As much as 50%–60% of cereal grains can be lost during storage. New technologies based on smart wireless sensors, data analytics, and advanced modeling software can address this challenge and reduce post-harvest losses.